|
KMID : 0624620120450050281
|
|
BMB Reports
2012 Volume.45 No. 5 p.281 ~ p.286
|
|
|
Effect of interferon-γ on the fusion of mononuclear osteoclasts into bone-resorbing osteoclasts
|
|
Kim Jeung-Woo
Lee Myeung-Su
Lee Chang-Hoon
Kim Ha-Young
Chae Soo-Uk
Kwak Han-Bok
Oh Jae-Min
|
|
|
Abstract
|
|
|
|
Osteoclasts are multinucleated cells that are formed by the fusion of pre-fusion osteoclasts (pOCs). The fusion of pOCs is known to be important for osteoclastic bone resorption. Here, we examined the effect of IFN-γ on the fusion of pOCs. IFN-γ greatly increased the fusion of pOCs in a dose-dependent manner. Furthermore, IFN-γ induced pOC fusion even in hydroxyapatite-coated plates used as a substitute for bone. The resorption area of pOCs stimulated with IFN-γ was significantly higher than that of the control cells. IFN-γ induced the expression of dendritic cell-specific transmembrane protein (DC-STAMP), which is responsible for the fusion of pOCs. IFN-γ enhanced DC-STAMP expression in a dose-dependent manner. The mRNA expression of c-Fos and nuclear factor of activated T cells (NFAT) c1 was enhanced in the pOCs treated with IFN-γ. Taken together, these results provide a new insight into the novel role of IFN-γ on the fusion of pOCs.
|
|
|
KEYWORD
|
|
|
Fusion, Interferon, Osteoclasts
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|